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Chronic alcohol consumption upregulates CYP2E1, 40 promoting ROS production in hepatocytes and nicotinamide adenine dinucleotide phosphate oxidase 4 overexpression

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Notably, although dietary OBS exhibited linear associations with DKD and low-eGFR ( Figures 2D, E ), it showed a non-linear association with albuminuria ( p for non-linearity = 0.021, p for overall = 0.004)

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles